Osteogenesis Imperfecta

Osteogenesis imperfecta Osteogenesis imperfecta (OI) is a r atomic number 18 genetic disorder of collagen synthesis associated with all-inclusive spectrum of musculoskeletal problems, most notably bowing and fractures of the extremities, muscle weakness, lassitude in the ligaments, and spinal deformities.(Binder, 386). early(a) collagen-containing skeletal tissues, such as the sclerae, the teeth, and the heart valves be as well as affected to a variable sum degree. OI has a common feature of bony fragility associated with toilsome formation of collagen by osteoblasts and fibroblasts(Smith, 1983, 13).

This disease, involving defective developm ent of the connective tissues, is normally the result of the autosomal dominant gene, but can withal be the result of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad (Binder, 386). OI is most commonly referred to as brickly bones,” but other names include: fragilitas o...If you want to inconvenience a full essay, order it on our website: OrderEssay.net

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