Explain The Action Of Poisons And Drugs On Enzymes

Poisonous substances ar deadly due to the personal manner that they act with enzymes, inhibiting them thus preventing them from working in the normal way. There ar many types of inhibitors of which include: nonspecific, which effect all enzymes the same way by denaturing the protein part of the molecule and therefore is irreversible, competitive inhibitors which be similar shapes to the substrate and therefore fit into the restless aim preventing the substrate from being catalysed and non-competitive inhibitors which interact with the enzyme but not the active site but react elsewhere on the enzyme and causes it to transmute the shape of the active site.
Cyanide is strong non-competitive inhibitor of cellular respiration, bear upon an enzyme found in the membrane of mitochondria called cytochrome c oxidase. The binding of nitril to cytochrome c oxidase prevents electrons being transported from the enzyme to oxygen. Due to this disruption can no longer aerobically respire to produce ATP for energy. Cells then anaerobic metabolise which induces lactic acidosis, a build-up lactic acid in the blood.



Initial symptoms of cyanide poisons are a red or pinkish complexion are the tissues in the victim are unable to use oxygen in the blood, and then swooning and cardiac arrest are shortly induced as tissues that mainly depend on aerobic respiration are those in the central nervous system and the heart. Lethal doses of cyanide can be as low as 1.5mg/kg body weight.
Poisoning due to ethylene glycol is caused by the ingestion of antifreeze use in car engines. The substance is colorless and odourless with a very sweet taste and is usually consumed by children or animals due to this sweetness. While the parent composite is not toxic, ethylene glycol metabolites are accountable for cellular damage in many tissues, especially the kidneys which are bear on by glycolic and oxalic acid. These metabolites are produced when ethylene glycol is broken push down by the enzyme alcohol dehydrogenase...If you want to get a secure essay, order it on our website: Orderessay



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